COVID-19 Research & Outreach
More than 32 CeZAP faculty affiliates continue to respond to the COVID-19 pandemic through research, education, and outreach activities, including developing vaccines and antivirals, studying the biology of the virus, providing undergraduate and graduate course lectures on COVID-19, and educating the public about aerosol transmission, vaccine, and public health measures in a large number of news media such as CNN, CBS, and NPR, etc.
CeZAP faculty affiliates published more than 40 papers on COVID-19 and continue to contribue to outreach efforts with daily mentions in national and top-tier media outlets.
Featured News Articles on COVID-19 research
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- Reza Ovissipour, Andrea Bertke and others receive $1 million USDA grant to study SARS-CoV-2 survival on surface of the food supply chain.
- James Weger-Lucarelli receives a $300,000 NSF grant to study obesity and coronavirus disease.
- Several CeZAP affiliated faculty receive OVPR COVID-19 research grants.
- Nisha Duggal, Linsey Marr, and Stanca Ciupe receive CeZAP pilot grant to study SARS-CoV-2 aerosol transmission in exhaled breath.
- Coy Allen and Pablo Sobrado receive a VTCDD $10,000 award to explore the role of NOD-like receptors in modulating inflammatory response in COVID-19.
An evaluation of a new rapid qPCR test for the detection of 2019-novel coronavirus nucleocapsid (N1) gene in wastewater in Roanoke and Salem VA sewersheds Lehrer LW, Lewis AM, Tolliver S, Degen M, Singh R, Houser S, Rao J. J Water Health DOI: 10.2166/wh.2024.085
SARS-CoV-2 Rapidly Infects Peripheral Sensory and Autonomic Neurons, Contributing to Central Nervous System Neuroinvasion before Viremia. Joyce JD, Moore GA, Goswami P, Harrell TL, Taylor TM, Hawks SA, Green JC, Jia M, Irwin MD, Leslie E, Duggal NK, Thompson CK,Bertke AS. Int J Mol Sci. DOI: 10.3390/ijms25158245.
Mathematical analysis of simple behavioral epidemic models. LeJeune L, Ghaffarzadegan N, Childs LM, Saucedo O.Math Biosci. DOI: 10.1016/j.mbs.2024.109250
Doff Thy Gown - Shedding Contact Precautions for COVID-19. Rabin AS, Marr LC, Blumberg HM. Clin Infect Dis DOI: 10.1093/cid/ciae276
A selective sweep in the Spike gene has driven SARS-CoV-2 human adaptation Kang L, He G, Sharp A, Wang X, Brown A, Michalak P, Weger-Lucarelli J. Cell DOI: 10.1016/j.cell.2021.07.007
Development and implementation of a scalable and versatile test for COVID-19 diagnostics in rural communities Ceci A, Munox-Ballester C, Tegge AN, Brown KL, Umans RA, Michel FM, Patel D, Tewari B, Martin J Alcoreza O, Maynard T Martine-Martine D, Bordwine P, Bissell N, Friedlander MJ, Sontheimer H, Finkielstein CV. Nature Communications DOI: 10.1038/s41467-021-24552-4
Airborne transmission of SARS-CoV-2 Prather KA, Marr LC, Schooley RT, McDiarmid MA, Wilson ME, Milton DK. Science. 2020 Oct 16;370(6514):303-304.doi:10.1126/science.abf0521
SARS-CoV-2 infection in the gastrointestinal tract: fecal-oral route of transmission for COVID-19? Meng XJ, Liang, TJ. Gastroenterology 2021 Jan 7:S0016-5085(21)00030-5. doi:10.1053/j.gastro.2021.01.005
BCG vaccine protection from severe coronavirus disease 2019 (COVID-19) Escobar LE, Molina-Cruz A, Barillas-Mury C. Proc Nal Acad Sci USA.2020 Jul 28;117(30):17720-17726.doi: 10.1073/pnas.2008410117
Covid‐19: One year on…. Fricker RD. Significance. (RSS and the ASA). 03 February 2021. doi: 10.1111/1740-9713.01485.
Individual quarantine versus active monitoring of contacts for the mitigation of COVID-19: a modeling study. Peak CM, Kahn R, Grad YH, Childs LM, Li R, Lipstitch M, Buckee CO. Lancet Infect Dis. 2020 Sep;20(9):1025-1033. doi: 10.1016/S1473-3099(20)30361-3.
Improved plaque assay for human coronaviruses 229E and OC43. Bracci N, Pan HC, Lehman C, Kehn-Hall K, Lin SC. PeerJ. 2020 Dec 21;8:e10639. doi: 10.7717/peerj.10639.
A selective sweep in the Spike gene has drive SARS-CoV-2 human adaptation. Kang L, G. He, A.K. Sharp, X. Wang, A.M. Brown, P. Michalak, J. Weger-Lucarelli. BioRxiv. doi:10.1101/2021.02.13.431090
PSGL-1 Inhibits the incorporation of SARS-CoV and SARS-CoV-2 spike glycoproteins into pseudovirions and impairs pseudovirus attachment and infectivity. He S, Waheed AA, Hetrick B, Dabbagh D, Akhrymuk IV, Kehn-Hall K, Freed EO, Wu Y. Viruses.2020 Dec 30;13(1):46; doi:10.3390/v13010046
Airborne transmission of SARS-CoV-2: What We Know. Samet JM, Parther K, Benjamin G, Lakdawala S, Lowe JM, Reingold A, Volckens J. Marr LC. Clin Infect Dis. 2021 Jan 18:ciab039. doi: 10.1093/cid/ciab039
Additively manufactured respirators: quantifying particle transmission and identifying system-level challenges for improving filtration efficiency. LB, Pan J, Harb C, Zawaski CE, Molla B, Kubalak JR, Marr LC, Williams CB. J Manuf Syst. 2021 Jan 20. doi: 10.1016/j.jmsy.2021.01.002
Uniting infectious disease and physical science principles on the importance of face masks for COVID-19. Gandhi M, Marr LC, Med (N Y) Jan 15;2(1):29-32. doi: 10.1016/j.medj.2020.12.008.
Can indoor sports centers be allowed to re-open during the COVID-19 pandemic based on a certificate of equivalence? Bloken B, van Druenen T, van Hooff T, Verstappen PA, Marchal T, Marr LC. Build Environ. 2020 Aug 180:107022. doi: 10.1016/j.buildenv.2020.107022
Transmission of SARS-CoV-2 by inhalation of respiratory aerosol in the Skagit Valley Chorale super spreading event. Miller SL, Nazaroff WW, Jimenez JL, Boerstra A, Buonanno G, Dancer SJ, Kuritski J, Marr LC, Morawska L, Noakes C. Indoor Air. 2020 Sep
SARS-CoV-2 indoor air transmission is a threat that can be addressed with science Samet J, Burke T, Lakdawala S, Lowe J, Marr LC, Prather K, Shelton-Davenport M, Volckens J. Proc Natl Acad Sci U S A DOI: 10.1073/pnas.2116155118
Reduction of Infectivity of SARS-CoV-2 by Zinc Oxide Coatings Hosseini M, Behzadinasab S, Chin A, Poon L, Ducker WA. ACS Biomater SCI Eng
DOI: 10.1021/acsbiomaterials.1c01076 26:10.1111/ina.12751.doi: 10.1111/ina.12751
Killed whole-genome reduced-bacteria surface-expressed coronavirus fusion peptide vaccines protect against disease in a porcine model Maeda D, Tian D, Yu H, Dar N, Rajasekaran V, Meng S, Mahsoub H, Sooryanarain H, Wang B, Heffron C, Hassebroek A, LeRoith T, Meng XJ, Zeichner S. Proc Natl Acad Sci U S A
DOI: 10.1073/pnas.2025622118
Filtration evaluation of expired elastomeric P-100 filter cartridges after months of real-world use during the coronavirus disease 2019 (COVID-19) pandemic Baffoe-Bonnie A, Zhang K, Pan J, Simpkins K, Marr L.
Infect Control Hosp Epidemiol
DOI: 10.1017/ice.2021.104
Dismantling myths on the airborne transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) Tang J. Bahnfleth W, Bluyssen P, Buonanno G, Jimenez J, Kurnitski J, Li Y, Miller S, Sekhar C, Morawska L, Marr L, Melikov A, Nazaroff W, Nielsen P, Tellier R, Wargocki P, Dancer S.
J Hosp Infect DOI: 10.1016/j.jhin.2020.12.022
Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids Hosseini M, Chin A, Behzadinasab S, Poon L, Ducker W. ACS Appl Mater Interfaces DOI: 10.1021/acsami.0c19465
Covid-19 has redefined airborne transmission Tang J, Marr L, Li Y, Dancer S. BMJ DOI: 10.1136/bmj.n913
SARS-CoV-2 Infection in the Gastrointestinal Tract: Fecal-Oral Route of Transmission for COVID-19? Meng XJ, Liang T Gastroenterology
DOI: 10.1053/j.gastro.2021.01.005
Quantification of the Tradeoff between Test Sensitivity and Test Frequency in a COVID-19 Epidemic-A Multi-Scale Modeling Approach Forde J, Ciupe S. Viruses DOI: 10.3390/v13030457
Targeting protein-protein interaction interfaces in COVID-19 drug discovery Chang C, Lin SM, Satange R, Lin SC, Sun SC, Wu HY, Kehn-Hall K, Hou MH. Comput. Struct. Biotechnol. J DOI: 10.1016/j.csbj.2021.04.003
Survival of Severe Acute REspiratory Syndrome Coronavirus s (SARS-CoV-2) and Herpes Simplex Virus 1 (HSV-1) on Foods Stored at Refrigerated Temperature Dhakal J, Jia M, Joyce J, Moore G, Ovissipour R, Bertke A. Foods DOI: 10.3390/foods10051005
Aerosols should not be defined by distance travelled Tang j, Marr LC, Milton D. J Hosp Infect DOI: 10.1016/j.jhin.2021.05.007
Adenovirus transduction to express human ACE2 causes obesity-specific morbidity in mice, impeding studies on the effect of host nutritional status on SARS-CoV-2 pathogenesis Rai P, Chuong C, LeRoith T, Smyth J, Panov J, Levi M, Kehn-Hall K, Duggal N, Weger Lucarelli J. Virology
DOI: 10.1016/j.virol.2021.08.014
A Paradigm Shift to Align Transmission Routes with Mechanisms Marr LC, Tang J. Clin Infect Dis DOI: 10.1093/cid/ciab722
Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses Morris D, Yinda K, Gamble A, Rossine F, Huang Q, Bushmaker T, Fischer R, Matson M, Doremalen N, Vikesland P, Marr LC, Munster V, Lloyd-Smith J. Elife DOI: 10.7554/eLife.65902
Airborne transmission of respiratory viruses Wang C, Prather K, Sznitman J, Jimenez J, Lakdawala S, Tufekci Z, Marr LC. Science DOI: 10.1126/science.abd9149
Relative Humidity Predicts Day-to-Day Variations in COVID-19 Cases in the City of Buenos Aires Rojas A, Cordo S, Saurral R, Jimenez J, Marr LC, Kropff E. Environ Sci Technol DOI: 10.1021/acs.est.1c02711
How did we get here: what are droplets and aerosols and how far do they go? A historical perspective on the transmission of respiratory infectious diseases Randall K, Ewing ET, Marr LC, Jimenez L, Bourouiba L. Interface Focus DOI: 10.1098/rsfs.2021.0049
Public Health Responses to Pandemics in 1918 and 2020 Ewing ET. Am J Public Health DOI: 10.2105/AJPH.2021.306453
The viability of SARS-CoV-2 on solid surfaces Hosseini M, Behzadinasab S, Benmamoun Z, Ducker WA. Curr Opin Colloid Interface Sci DOI: 10.1016/j.cocis.2021.101481
Risk of SARS-CoV-2 Transmission among Air Passengers in China Hu M, Wang J, Lin H, Ruktanonchai C, Xu C, Meng B, Zhang X, Carioli A, Feng Y, Yin Q, Floyd J, Ruktanonchai NW, Li Z, Yang W, Tatem A, Lai S
Clin Infect Dis DOI: 10.1093/cid/ciab836
Infectious SARS-CoV-2 is Emitted in Aerosol Particles Hawks S, Prussin A, Kuckinsky S, Pan J, Marr LC, Duggal N. MBio DOI: 10.1128/mBio.02527-21
Transparent and Sprayable Surface Coatings that Kill Drug-Resistant Bacteria Within Minutes and Inactivate SARS-CoV-2 Virus Behzadinasab S, Williams M, Hosseini M, Pon L, Chin A, Falkinham J, Ducker WA. ACP Appl Mater Interfaces
DOI: 10.1021/acsami.1c15505
Effect of non-pharmaceutical interventions ton contain COVID-19 in China Lai S, Ruktanonchai NW, Zhou L, Prosper O, Luo W, Floyd J, Wesolowski A, Santillana M, Zhang C, Du x, Yu H, Tatem A. Nature DOI: 10.1038/s41586-020-2293-x
Untangling introdutions and persistence in COVID-19 resurgence in Europe Lemey P, Ruktanonchai NW, Hong S, Collizza V, Poletto C, Van Den Broeck F, Gill M, Ji X, Levasseur A, Munnink B, Koopmans M, Sadilek A, Lai S, Tatem A, Baele G, Suchard M, Dellicour S. Nature DOI: 10.1038/s41586-021-03754-2
Risk of SARS-CoV-2 Transmission among Air Passengers in China Hu M, Wang J, Lin H, Ruktanonchai C, Xu C, Meng B, Zhang X, Carioli A, Feng Y, Yin Q, Floyd J, Ruktanonchai NW, Li Z, Yang W, Tatem A, Lai S Clin Infect Dis DOI: 10.1093/cid/ciab836
Uncovering two phases of early intercontinental COVID-19 transmission dynamics Yang J, Li J, Lai S, Ruktanonchai C, Xing W, Carioli A, Wang P, Ruktanonchai NW, Li R, Floyd J, Wang L, Bi Y, Shi W, Tatem A. J Travel Med DOI: 10.1093/jtm/taaa200
Integrated vaccination and physical distancing interventions to prevent future COVID-19 waves in Chinese cities Huang B, Wang J, Cai J, Yao S, Chan P, Tam T, Hong Y, Ruktanonchai C, Carioli A, Floyd J Ruktanonchai NW, Yang W, Li Z, Tatem A, Lai S. Nat Hum Behav DOI: 10.1038/s41562-021-01063-2
Assessing the Effect of Global Travel and Contact Restrictions on Mitigating the COVID-19 Pandemic Lei S, Ruktanonchai NW, Carioli A, Ruktanonchai C, Floyd J, Prosper O, Zhang C, Du X, Yang W, Tatem A. Engineering (Beijing) DOI: 10.1016/j.eng.2021.03.017
SARS-CoV-2 European resurgence foretold: interplay of introductions aind persistence by leveraging genomic and mobility data Lemey P, Ruktanonchai N, Hong S, Colizza V, Poletto C, Van den Broek F, Gill M, Ji X, Levasseur A, Sadilek A, Lai S, Tatem A, Baele G, Suchard M, Dellicour S. Res Sq DOI: 10.21203/rs.3.rs-208849/v1
Effect of non-pharmaceutical interventions for containing the COVID-10 outbreak in China Lai S, Ruktanonchai N, Zhou L, Prosper O, Luo W, Floyd J, Wesolowski A, Santillana M, Zhang C, Du X, Yu H, Tatem A. medRxiv DOI: 10.1101/2020.03.03.20029843
SARS-CoV-2 virus transfers to skin through contact with contaminated solids Behzadinasab S, Chin A, Hosseini M, Poom L, Ducker WA. Sci Rep DOI: 10.1038/s41598-021-00843-0
Requirements for the containment of COVID-19 disease outbreaks through periodic testing, isolation, and quarantine Mukhamadiarov R, Den gS, Serrao S Prianka Childs L, Tauber U. J. Phys. A Math Theor. DOI: 10.1088/1751-8121/ac3fc3
COVID-19 Seroprevalence in Canada ModellingWaning and Boosting COVID-19 Immunity in Canada a Canadian Immunization Research Network Study Dick, DW; Childs, L, Feng Z, Li J, Rost G, Buckeridge DL, Ogden NH, Heffernan JM. Vaccines 10.3390/vaccines10010017
SARS-CoV-2 on Surfaces and HVAC Filters in Dormitory Rooms Pan J, Hawks S, Prussin II A, Duggal NK, Marr LC. Environ Sci Technol Lett DOI: 10.1021/acs.estlett.1c00892
Reducing Transmission of Airborne Respiratory Pathogens: A New Beginning as the COVID-19 Emergency Ends Marr LC, Samet JM. Environ Health Perspect DOI: 10.1289/EHP13878
SARS-CoV-2 Specific Nanobodies Neutralize Different Variants of Concern and Reduce Virus Load in the Brain of h-ACE2 Transgenic Mice Pavan MF, Bok M, San Juan RB, Malito JP, Marcoppido GA, Franco DR, Militelo DA, Schammas JM, Bari SE, Stone W, Lopez K, Porier DL, Muller JA, Auguste AJ, Yuan L, Wigdorovitz A, Parreno VG, Ibanez LI. Viruses DOI: 10.3390/v16020185
Machine learning-driven SERS fingerprinting of disintegrated viral components for rapid detection of SARS-CoV-2 in environmental dust. Garg A, Hawks S, Pan J, Wang W, Duggal N, Marr LC, Vikesland P, Zhou W. Biosens Bioelectron DOI: 10.1016/j.bios.2023.115946
A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection. Coria LM, Rodriguez JM, Demaria A, Bruno LA, Medrano MR, Castro CP, Castro EF, Del Priore SA, Hernando Insua AC, Kaufmann IG, Saposnik LM, Stone WB, Prado L, Notaro US, Amweg AN, Diaz PU, Avaro M, Ortega H, Ceballos A, Krum V, Zurvarra FM, Sidabra JE, Drehe I, Baqué JA, Li Causi M, De Nichilo AV, Payes CJ, Southard T, Vega JC, Auguste AJ, Álvarez DE, Flo JM, Pasquevich KA, Cassataro J. Nat Commun DOI: 10.1038/s41467-024-45180-8.
COVID-19 related messaging, beliefs, information sources, and mitigation behaviors in Virginia: a cross-sectional survey in the summer of 2020. Silverman RA, Short D, Wenzel S, Friesen MA, Cook NE Peer J DOI: 10.7717/peerj.16714